Tolerability of Chemoprophylactic Mefloquine
نویسندگان
چکیده
منابع مشابه
The Italian army standpoint on malaria chemoprophylaxis.
Soldiers on duty in tropical areas are at high risk of malaria and need chemoprophylactic regimens which may ensure the best efficacy, tolerability and compliance. Current Italian Army guidelines are based on recent military experiences in tropical areas, where mefloquine prophylaxis was as well tolerated as combination treatment with chloroquine and proguanil but more effective and easier to c...
متن کاملActivity in vitro of chloroquine, cycloguanil, and mefloquine against African isolates of Plasmodium falciparum: presumptive evidence for chemoprophylactic efficacy in Central and West Africa.
Discussion Although multiresistant P. faldipamm is an increasing problem, reports of P . vivax resistant to chloroquine have been few. The above case reports document the presence of chloroquine-resistant P. vivax in India, and show that it may not be as rare as it i s presumed to be. Also, the number of drug resistant strains is probably increasing. Antimalarial drugs other than chloroquine us...
متن کاملRandomized, double-blind study of the safety, tolerability, and efficacy of tafenoquine versus mefloquine for malaria prophylaxis in nonimmune subjects.
This study represents the first phase III trial of the safety, tolerability, and effectiveness of tafenoquine for malaria prophylaxis. In a randomized (3:1), double-blinded study, Australian soldiers received weekly malaria prophylaxis with 200 mg tafenoquine (492 subjects) or 250 mg mefloquine (162 subjects) for 6 months on a peacekeeping deployment to East Timor. After returning to Australia,...
متن کاملTolerability and Efficacy of a Pediatric Granule Formulation of Artesunate-Mefloquine in Young Children from Cameroon with Uncomplicated Falciparum Malaria
A fixed-dose pediatric formulation of artesunate and mefloquine (Artequin Pediatric) has been developed. In this open, non-comparative study in Cameroonian children with uncomplicated falciparum malaria, the safety and efficacy of this formulation was tested, with a particular emphasis on the risk of neuropsychiatric adverse events (AEs). In total, 220 subjects, weighing between 10 and 20 kg, w...
متن کاملPharmacokinetics of prophylactic mefloquine.
The pharmacokinetics of the prophylactic dose of mefloquine (Lariam: 500 mg every 4 weeks, with a loading dose of 750 mg on the first week) was studied in six healthy Thai male volunteers. Mefloquine was well tolerated during the study period of 16 weeks. The only side-effects found were nausea and diarrhea in 2 volunteers after the first dose of mefloquine. The mean minimum concentration of me...
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ژورنال
عنوان ژورنال: Journal of Travel Medicine
سال: 1995
ISSN: 1195-1982,1708-8305
DOI: 10.1111/j.1708-8305.1995.tb00626.x